We have several funded studies being prepared for recruitment:
(1) Identifying the Optimal Neural Target for Misophonia Interventions
In order to develop treatments for Misophonia, it is important to gain a better understanding about what is happening in the brain when people with Misophonia (and those without) are triggered by misophonic and non-misophonic cues. In this study (PI: Neacsiu) funded by the REAM Foundation and supported by CMER, the primary aim is to disentangle the brain circuitry dysfunction in Misophonia when compared to highly emotional dysregulated adults without Misophonia. A secondary aim is to examine changes in misophonic distress and regulation when applying inhibitory, excitatory, or sham repetitive transcranial magnetic stimulation (rTMS) over key neural networks.
(2) Exploring the acceptability, feasibility, and efficacy of two treatments for misophonia
While we continue to work on better understanding Misophonia, it is also important to identify treatments that can help people who are currently suffering. Further, it is important that the treatments we provide are acceptable to the people who receive them. In this study, participants will complete one of two treatments we believe can help manage symptoms of Misophonia: The Unified Protocol or Process-Based Therapy. Both treatments will use evidence-based psychological principles (e.g., managing attention or behavior) in a flexible manner and will focus on developing skills to help reduce the distress and impairment associated with Misophonia. The aims of this study are (1) to explore the acceptability and feasibility of these treatments for individuals who experience Misophonia and (2) to examine whether these treatments help reduce symptoms associated with Misophonia.
(3) Developing an interview to assess experiences with Misophonia
This study aims to develop and validate a semi-structured clinical interview to assess Misophonia in adults by means of two phases. The first phase will pilot an initial version of the interview within a small sample to evaluate feasibility and acceptability of the instrument by participants with Misophonia. After integrating participant and expert feedback, Phase 2 will involve administration of the Misophonia interview to a large sample of adults with Misophonia. The outcome of this study will be a validated interview that clinicians can use with their patients to better understand their symptoms and the impact of Misophonia in their everyday lives, and that researchers can use in future research on this sound-intolerance condition.
(4) Identifying sounds to use in Misophonia research
The aim of this study is to validate a set of standardized sounds to use in research for those suffering from Misophonia. An additional aim of this study is to explore interpersonal functioning in the context of Misophonia.